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Optimal lipid composition of Outer Mitochondrial Membrane (OMM) for MD runs
- z.sichaib
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4 years 8 months ago #8186
by z.sichaib
Optimal lipid composition of Outer Mitochondrial Membrane (OMM) for MD runs was created by z.sichaib
Dear Martini Users,
I am interested to run CG simulations with Martini FF of a protein in a realistic OMM.
I was wondering, what would be the possible optimum composition for representing the OMM bilayer?
I read that the lipid composition of the OMM is not identical when compared with different cell types/tissues? and we might have asymmetries in lipid distribution across the lipid bilayer of the OMM ( doi.org/10.1016/j.plipres.2013.07.002 ).
There are too many things to consider which make me confused about the lipid composition/ratio that I should use to model the OMM for MD runs. Did someone model the OMM before? I am still looking forward to some discussion.
I am interested to run CG simulations with Martini FF of a protein in a realistic OMM.
I was wondering, what would be the possible optimum composition for representing the OMM bilayer?
I read that the lipid composition of the OMM is not identical when compared with different cell types/tissues? and we might have asymmetries in lipid distribution across the lipid bilayer of the OMM ( doi.org/10.1016/j.plipres.2013.07.002 ).
There are too many things to consider which make me confused about the lipid composition/ratio that I should use to model the OMM for MD runs. Did someone model the OMM before? I am still looking forward to some discussion.
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- xavier
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4 years 7 months ago #8217
by xavier
Replied by xavier on topic Optimal lipid composition of Outer Mitochondrial Membrane (OMM) for MD runs
To my best knowledge no one has simulated a realistic OMM.
Your best shot is to decide of a generic composition that would be the most faithful to most cells and tissue types.
Your best shot is to decide of a generic composition that would be the most faithful to most cells and tissue types.
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