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Flip-flop in bilayer
- dariush
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10 years 4 weeks ago #3623
by dariush
Flip-flop in bilayer was created by dariush
Is there anybody, who observed flip-flop in the bilayer simulation using MARTINI? Pure bilayer or mixed one?
Could you please share the conditions?
Could you please share the conditions?
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- helgi
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10 years 4 weeks ago #3624
by helgi
Replied by helgi on topic Flip-flop in bilayer
Short, off the top of my head answer
No "normal" Martini lipids do not flip-flop on the few microsecond time scale without some bilayer defect / pore etc. But cholesterol does and so would specific "strange" lipids like e.g. diacylglycerols.
Cheers,
- Helgi
No "normal" Martini lipids do not flip-flop on the few microsecond time scale without some bilayer defect / pore etc. But cholesterol does and so would specific "strange" lipids like e.g. diacylglycerols.
Cheers,
- Helgi
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- dariush
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10 years 4 weeks ago #3625
by dariush
Replied by dariush on topic Flip-flop in bilayer
Thanks!
Is there any publication on this subject - using MARTINI? I found a paper, but it is full atomistic:
Replacing the cholesterol hydroxyl group by the ketone group facilitates sterol flip-flop and promotes membrane fluidity, T. Rog, L.M. Stimson, M. Pasenkiewicz-Gierula, I. Vattulainen, M. Karttunen, J. Phys. Chem. B. 112 1946-1952 (2008).
Is there any publication on this subject - using MARTINI? I found a paper, but it is full atomistic:
Replacing the cholesterol hydroxyl group by the ketone group facilitates sterol flip-flop and promotes membrane fluidity, T. Rog, L.M. Stimson, M. Pasenkiewicz-Gierula, I. Vattulainen, M. Karttunen, J. Phys. Chem. B. 112 1946-1952 (2008).
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10 years 4 weeks ago - 10 years 4 weeks ago #3626
by mnmelo
Replied by mnmelo on topic Flip-flop in bilayer
Regarding cholesterol flip-flop:
pubs.acs.org/doi/abs/10.1021/ja076641c
pubs.acs.org/doi/full/10.1021/ja903529f (also AA)
pubs.acs.org/doi/abs/10.1021/ja076641c
pubs.acs.org/doi/full/10.1021/ja903529f (also AA)
Last edit: 10 years 4 weeks ago by mnmelo.
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