Lipid fingerprints

fingerprintThe large variety of lipids in the plasma membrane gives rise to very complex protein-lipid interactions. These interactions, coined fingeprints, are analyzed in the following paper, based on the Martini model (what else?):

V. Corradi et al. Lipid–Protein Interactions Are Unique Fingerprints for Membrane Proteins. ACS Cent. Sci., asap, 2018. DOI:10.1021/acscentsci.8b00143

Curvature-induced lipid sorting

PM tehters cover 02c(1)

By pulling tethers from realistic plasma membranes we have been able to identify to what extent lipids are being sorted as a result of curvature. We show that some lipids are depleted from highly curved regions, whereas other are being enriched. But everything also depends on the pulling direction, as the plasma membrane is asymmetric. For details, see the paper which is now available online in the new flagship journal of Wiley:

S. Baoukina, H.I. Ingólfsson, S.J. Marrink, D.P. Tieleman. Curvature‐Induced Sorting of Lipids in Plasma Membrane Tethers. Advanced Theory and Simulations,


Martini 3.0 before the Summer

The long awaited (beta) release date of the new Martini 3.0 model is finally there: July 1st, 2018.

Only 3 weeks to go, and all your Martini worries will be gone !

Review on supramolecular systems

Interested in supramolecular self-assembly ? Check out this review from our group, featuring many Martini-based simulations:

P.W.J.M. Frederix, I. Patmanidis, S.J. Marrink. Molecular simulations of self-assembling bio-inspired supramolecular systems and their connection to experiments. Chem. Soc. Review, in press, 2018. doi:10.1039/C8CS00040A

TOC CSR simple

Martini 3 cocktail release

With a major new release of the Martini force field (Martini 3.0) imminent, it is also appropriate to perform an update on the inspiration for the force field: the Martini cocktail. We know the Classic Martini, Vodka Martini, Dirty Martini, Perfect Martini, Dry Martini and other, but after an evening of hard work we now have the official Martini 3.0 cocktail too! See here for a detailed decription how to mix it. Enjoy !