The Martini Coarse-Grained Force Field

Book chapter
Protocol
Forcefield
Parametrization
Author

Xavier Periole & Siewert-Jan Marrink

Doi

https://doi.org/10.1007/978-1-62703-017-5_20

Citation (APA 7)

Periole, X., & Marrink, S. J. (2013). The Martini coarse-grained force field. Biomolecular simulations: Methods and protocols, 533-565.

Abstract

The Martini force field is a coarse-grained force field suited for molecular dynamics simulations of biomolecular systems. The force field has been parameterized in a systematic way, based on the reproduction of partitioning free energies between polar and apolar phases of a large number of chemical compounds. In this chapter the methodology underlying the force field is presented together with details of its parameterization and limitations. Then currently available topologies are described with a short overview of the key elements of their parameterization. These include the new polarizable Martini water model. A set of three selected ongoing studies using the Martini force field is presented. Finally the latest lines of development are discussed.